An Achilles' heel for breast cancer?
Caldecott KW, Chalmers A. Nat Struct Mol Biol. 2005 May;12(5):387-8
Two recent reports describe potentially novel therapeutic approaches for treating tumors arising from mutations in the tumor suppressor genes BRCA1 and BRCA2. These studies support the idea that selective killing of tumor cells can be achieved by targeting a specific DNA repair pathway on which an individual tumor type has become dependent.