Thursday, December 08, 2005

News for ER+ Breast Cancer: Estrogen Can Kill Cells That Were Once Fueled By It

Science News Daily via the Fox Chase Cancer Center December 07, 2005
Women with Estrogen Receptor Positive (ER+) breast cancers are treated with drugs like Tamoxifen, fulvestrant, or aromatase inhibitors. These drugs block estrogen in cells that need it to live, which causes those cells to die. Over time, the cancer cells learn to adapt and estrogen blocking medicines no longer work. Researchers at the Fox Chase Cancer Center discovered that those adapted breast cancer cells die when they are re-introduced to estrogen so that breast cancer cells that were once fueled by estrogen can be killed by it. This raises the possibility that estrogen therapy after estrogen deprivation may overcome the cells' eventual resistance to hormone therapy.


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