Monday, April 03, 2006

Translational Derepression & Oncogene Expression In Breast Cancer Cells

Medical News Today, April 03, 2006
Drs. Anuradha Mehta, Christopher Trotta and Stuart Peltz (PTC Therapeutics) have uncovered a novel mechanism whereby the translation efficiency of oncogenes is increased in cancer cells. The human epidermal growth factor receptor 2 (Her-2) is an established oncogene whose overexpression drives metastasis in about 25% of breast cancer patients. In the April 15th issue of Genes & Development, the researchers report that an element within the 3' untranslated region (UTR) of Her2 mRNA can inhibit translational repression by the 5' upstream open reading frame (uORF), and thereby increase Her2 translation in breast cancer cells. ----Click the title of this post to read the full article from its source--


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