A new study finds the strongest evidence yet for the hypothesis that widespread environmental exposure to bisphenol A during fetal life causes breast cancer in adult women. [The researchers] exposed pregnant rats to bisphenol A at doses ranging from 2.5 to 1,000 µg per kg of body weight per day. By the time the pups exposed at the lowest dose reached the equivalent of puberty (50 days old), about 25% of their mammary ducts had precancerous lesions, a proportion three to four times higher than among the nonexposed controls. Mammary ducts from all other exposure groups showed elevated levels of lesions. Cancerous lesions were found in the mammary glands of one-third of the rats exposed to 250 µg/kg/day.
Bisphenol A, a known estrogenic compound, is ubiquitous in the environment. Many people receive exposures of about 2.5 µg/kg/day, and mammary gland development in rats and humans is very similar. Therefore, Soto says, "bisphenol A could be one factor causing the increase in breast cancer incidence over the past 50 years." --Click the title of this post to read the full article from its source--
Labels: genetic predisposition, risks